Lysosomes, chromosomes and cancer

Lysosomes in cancer cells.

Genes, Chromosomes and Cancer

About 70 scientists recently attended the conference on " Aneuploidy and Cancer " in Oakland, CA, which was organized by P. Duesberg and D. Rasnick from the University of California, Berkeley, and generously sponsored by philanthropist Robert Leppo. The conference explored whether aneuploidy, i.e., specific ge-nomic imbalances, is a driving force behind the development of cancer. A century ago ...

Connecting chromosomes, crisis, and cancer.

Cancer is a disease of impaired genome stability. The molecular forces that maintain genome integrity and sense altered chromosome structure are invariably subverted in cancer cells. Here, we explore the contrasting contributions of telomeres in the initiation and suppression of cancer and review the evidence supporting a role for telomere dysfunction as a mechanism driving the radical chromoso...

Chromosomes and Cancer, Boveri Revisited

Already in the late 19th century, the link between chromosomal aberrations and the pathogenesis of cancer was described by von Hanssemann [9]. Moreover, as early as the first decade of the 20th century the German zoologist Theodor Boveri developed a genetic theory of cancer based on these chromosomal aberrations [3]. Until quite recently, these ideas have received only limited attention and foc...

Role of lysosomes in cancer therapy

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